Best Natural Supplements for Depression in UK (2025)

Feeling low, tired, or just not yourself? Depression affects millions across the UK, with about 1 in 4 people experiencing it at some point in their lives. While professional support is always recommended, many are searching for natural supplements to help manage symptoms and support their mental health. Here, we break down the latest research, trusted remedies, and practical tips for finding the right natural supplements for depression in the UK.

For those looking to ease stress and improve mood through daily routines, natural gummies offer a convenient and effective solution. Whether you’re exploring the calming effects of Ashwagandha gummies, need help winding down with relaxing gummies, or want to improve your rest with sleep gummies, there’s a growing range of options in the UK. You can also check out the top-rated calming gummies designed to naturally support emotional balance and reduce daily tension.

Discover Our Best Calming Gummies - Nuchu

Understanding Depression: Why Natural Support Matters

Depression isn’t just feeling sad; it can affect your energy, sleep, appetite, and even your physical health. Symptoms can include:

• Persistent sadness or hopelessness

• Loss of interest in activities

• Fatigue or low energy

• Sleep problems

• Changes in appetite

• Trouble concentrating

• Physical aches and pains

While medication and therapy are proven treatments, natural supplements can offer extra support, especially for mild to moderate symptoms. Always speak to your GP before starting any new supplement, especially if you’re taking other medication.

Top Natural Supplements for Depression

Here’s a look at the most researched and promising natural supplements for depression, based on recent studies and expert advice.

1. Nuchu  - Best Natural Supplements for Depression in UK (2025)

Nuchu Calming Gummies

Description (Calming Gummies):

Unwind and embrace tranquility with our plant extract-infused vitamin gummies, designed to promote calm and relaxation. Each bottle contains 60 gummies, offering a delightful daily dose of serenity.

Key Features:

• 60 gummies per bottle

• Strawberry flavored

• Vegan-friendly

• No artificial additives

• No added sugars OR sweeteners

• Gut-friendly

• Packed with prebiotic fibre

Composition and Benefits:

Our Calming gummies are formulated with three primary active ingredients:

1. Vitamin B6: Aids in serotonin production, promoting mood regulation.

2. Vitamin B12: Supports healthy nerve function.

3. Ashwagandha: Helps regulate cortisol levels, reducing stress.

Nutritional Information:

Ingredients:

Our gummies are made with natural ingredients, including FOS (Fructooligosaccharides), pectin, ashwagandha root extract, and natural flavouring. They contain no artificial sweeteners or additives.

Usage Instructions:

Take 2 gummies per day for optimal results.

2. Omega-3 Fatty Acids

Omega-3s, found in fish oil and algae, are essential for brain health. Research shows they can help reduce symptoms of depression, especially when combined with other treatments. EPA and DHA are the key types to look for.

• Recommended dose: 1,000–2,000 mg combined EPA/DHA daily

• Best sources: Oily fish (salmon, mackerel), high-quality supplements

3. Vitamin D

Vitamin D deficiency is common in the UK, especially during the winter. Low levels are linked to a higher risk of depression and Seasonal Affective Disorder (SAD). Supplementing with vitamin D3 can support mood and overall health.

• Recommended dose: 1,000 IU (25 mcg) daily, or as advised by your GP

• Best sources: Sunlight, fortified foods, supplements

4. B Vitamins (B6, B9, B12)

B vitamins play a big role in brain function and mood regulation. Deficiencies in B6, B9 (folate), and B12 are linked to depression. Supplementing can help support neurotransmitter production and energy.

• Recommended dose: As part of a B complex, or as advised by your GP

• Best sources: Whole grains, leafy greens, eggs, supplements

5. Magnesium

Magnesium helps regulate mood and the nervous system. Low magnesium is linked to a higher risk of depression, and studies show that supplementation can improve symptoms.

• Recommended dose: 200–400 mg daily

• Best sources: Nuts, seeds, leafy greens, magnesium supplements

6. 5-HTP (5-Hydroxytryptophan)

5-HTP is a natural precursor to serotonin, the “feel-good” brain chemical. Some studies show it can help reduce symptoms of depression, especially when combined with other treatments.

• Recommended dose: 100–300 mg daily (consult your GP first)

• Caution: Can interact with antidepressants; always check with your doctor

7. Saffron

Saffron, a spice from the crocus flower, is gaining attention for its mood boosting effects. Clinical trials suggest it can be as effective as some prescription antidepressants for mild to moderate depression, with minimal side effects.

• Recommended dose: 30 mg daily (standardised extract)

• Best sources: High-quality saffron supplements

8. Rhodiola Rosea

Rhodiola is an adaptogenic herb that helps the body manage stress and fatigue. Studies show it can reduce symptoms of depression and improve overall wellbeing.

• Recommended dose: 200–400 mg daily (standardised extract)

• Best sources: Rhodiola supplements

9. Ashwagandha

Ashwagandha is another adaptogen, known for its stress-reducing and mood-balancing effects. It may help lower cortisol (the stress hormone) and support resilience against stress and low mood.

• Recommended dose: 300–600 mg daily (standardised extract)

• Best sources: Ashwagandha supplements

Discover Our Best Ashwagandha Gummies

10. Lavender & Chamomile

Both lavender and chamomile are known for their calming effects. Lavender oil, in particular, has been shown to help with mild depression and anxiety, especially when used in aromatherapy or as a supplement.

• How to use: Inhale essential oils, use in a diffuser, or take as a supplement (as directed)

Lifestyle Tips: Natural Ways to Boost Mood

Supplements work best when paired with healthy habits. Consider these science-backed lifestyle changes:

• Exercise regularly: Just 30 minutes of walking can lift mood.

• Eat a balanced diet: Focus on whole foods, healthy fats, and plenty of veg.

• Prioritise sleep: Aim for 7–9 hours per night.

• Practice mindfulness: Mindfulness and meditation are proven to help prevent depression relapse.

• Limit alcohol and sugar: Both can worsen mood swings and energy crashes.

Safety First: What to Watch Out For

Natural doesn’t always mean safe. Some supplements can interact with medications or cause side effects. Always:

• Speak to your GP or pharmacist before starting a new supplement.

• Buy from reputable brands with third-party testing.

• Watch for changes in symptoms and report concerns to a healthcare professional.

If you or someone you know is struggling with severe depression or thoughts of self-harm, seek help immediately from your GP, NHS 111, or a mental health helpline.

Discover Our Best Calming Gummies - Nuchu